Membrane bending: the power of protein imbalance

摘要: Many cellular processes require membrane deformation, which is driven by specialized protein machinery and can often be recapitulated using pure lipid bilayers. However, biological membranes contain a large amount of embedded proteins. Recent research suggests that membranebound proteins with asymmetric distribution mass across the bilayer influence bending in nonspecific manner due to molecular crowding. This mechanism physical nature arises from collisions between such ‘mushroom-shaped’ It either facilitate or impede action coats, for example COPII, during vesicle budding. We describe physics how crowding discuss implications other processes, as sorting glycosylphosphatidylinositol-anchored (GPI-APs) production intraluminal vesicles. Bending Biological are complex mixture various species molecules more less [1]. They also highly dynamic terms their composition, shape, packing density [2,3]. key ability mediate reactions inside cell. For example, formation transport vesicles trafficking carefully orchestrated multistage process involving accumulation cargo, into bud, finally, scission