MHC-Antigen Interaction: What Does the T Cell Receptor See?

摘要: Publisher Summary It was recognized that in most cases the antigen is processed by antigen-presenting cells (APC), such fragments of antigen, rather than per se, are presented major histocompatibility complex (MHC) molecules and T (TcRs). There numerous examples synthetic peptides corresponding to defined portions protein antigens actually substitute for well-defined immunological reactions involving cells. In several instances, it shown directly bind MHC molecules. So far, however, biochemical data scarce binding often inferred from functional assays recognition TcRs. well known highly polymorphic. Polymorphism may influence both presentation TcRs many ways. Polymorphic residues peptide-binding site selection a given set native as their conformation orientation. Other polymorphic positively or negatively interfere with bound peptide TcR. The purpose this chapter survey recent critically analyze interpretation. shows can fit within consistent, though hypothetical, framework MHC-antigen-TcR interactions.