Maternal Deprivation Influences Pup Ultrasonic Vocalizations of C57BL/6J Mice.

摘要: Maternal deprivation (MD) is frequently used as an early life stress model in rodents to investigate behavioral and neurological responses under stressful conditions. However, the effect of MD on postnatal development rodents, which when multiple neural systems become established, rarely investigated due methodological limitations. Ultrasonic vocalizations (USVs) are one few produced by neonatal that can be quantitatively analyzed, quantification USVs regarded a novel approach possible alterations neurobehavioral emotional infant stress. To pup mice, we subjected C57BL/6J mice recorded pups days 1, 3, 7, 8, 14. determine whether was acute or cumulative, pre- post-separation USV groups were included; sex differences emission also investigated. Our results suggest (i) activity high 3–8; (ii) acute, cumulative not found; (iii) vocalized more longer than controls at lower frequency, closely related age; (iv) female susceptible males number duration between 3–8.