In vivo effects of bacterial lipopolysaccharide on proliferation of macrophage colony-forming cells in bone marrow and peripheral lymphoid tissues.

摘要: Changes in the number of macrophage colony-forming cells various tissues mice injected with lipopolysaccharide (LPS) from Klebsiella pneumoniae, Escherichia coli, or Salmonella enteritidis were studied. The injection LPS increased peripheral lymphoid such as spleen, mesenteric lymph nodes, and regional node, although same treatment caused decrease bone marrow. This phenomenon was consistently observed when tested by LPSs. into which had been exposed to X-ray irradiation reconstituted syngeneic normal marrow decreased spleen. increase spleen seemed, therefore, not be due migration appeared shorten lag time before initiation mitosis but No participation serum factors this could detected. It suggested that there might an essential difference between responsiveness those