Anti-tumor activity of the methanolic extracts of Salvia menthifolia
作者： Giovina Fiore , Paola Massarelli , Maurizio Sajeva , Gian Gabriele Franchi
DOI: 10.1590/S0102-695X2011005000220
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摘要: In the present research we investigated anti-proliferative activity of Salvia menthifolia Ten. (formerly menthaefolia), Lamiaceae, on a glioblastoma cell line, since up to date poor therapeutic results have been reported for treatment malignant glioblastoma. Methanol extracts from different anatomical parts S. were tested DBTRG-05MG line by MTT assay. The most active primary stems extract was also evaluated apoptosis induction. Results confirmed anti-tumor property all organs and demonstrated that induced after 4 h with highest values DNA fragmentation 6 24 h. Some HPLC analyzed polyphenols, althought activities could be due other constituents synergistic interactions. Rosmarinic acid, caffeic luteolin-7-O-glucosyde quercitrin found in extracts. good performance revealed towards this extremely aggressive human confirms genus is natural source agents though there are great differences among various species.
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