Enzymatic Mechanisms of Red Cell Adaptation to Anemia

摘要: It has long been known that many anemic patients adjust to their low hemoglobin levels and tend have clinical symptoms less severe than might be expected. is now generally accepted the increased level of DPG in red blood cells plays a major role this adjustment through its right- shifting effect on erythrocyte-oxygen affinity curve. The biochemical mechanisms by which are anemia yet satisfactorily demonstrated. produced two enzyme shunt glycolytic pathway (Rapoport Luebering, 1950). bypasses an ATP producing enzyme, phosphoglycerate kinase. There three possible may elevated: first, block lower part pathway, trivial our considerations here because it leads decreased glycolysis hemolytic if enough. second mechanism for elevating would increase activity relative kinase step. seems unlikely predominant implies there should tendency not case most types anemia.