Triiodothyronine: a substrate for the thermostable and thermolabile forms of human phenol sulfotransferase.
作者： WILLIAM F. YOUNG , COLUM A. GORMAN , RICHARD M. WEINSHILBOUM
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摘要: The enzyme(s) responsible for the sulfate conjugation of L-T3 in man has not been characterized. T3 sulfotransferase (T3-ST) activity was characterized normal human liver tissue obtained during clinically indicated surgical resection. Subcellular distribution studies showed that T3-ST localized to cytoplasmic fraction. This finding raised possibility might be similar 2 previously identified forms phenol (PST) found tissue. A thermostable (TS) form PST catalyzes micromolar concentrations p-nitrophenol, and a thermolabile (TL) dopamine other monoamines. Thermal stability enzyme inhibitor experiments pooled homogenates very TS PST. apparent similarity studied further by measuring T3-ST, PST, TL activities 20 individual sampl...
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R M Weinshilboum, Phenol sulfotransferase in humans: properties, regulation, and function. Federation proceedings. ,vol. 45, pp. 2223- 2228 ,(1986)
Glen Rein, Vivette Glover, Merton Sandler, Multiple forms of phenolsulphotransferase in human tissues: selective inhibition by dichloronitrophenol. Biochemical Pharmacology. ,vol. 31, pp. 1893- 1897 ,(1982) , 10.1016/0006-2952(82)90493-2
Gerhard Levy, Leo Stern, Narinder N. Khanna, David M. Soda, Osami Tsuzuki, Pharmacokinetics of acetaminophen in the human neonate: formation of acetaminophen glucuronide and sulfate in relation to plasma bilirubin concentration and D-glucaric acid excretion. Pediatrics. ,vol. 55, pp. 818- 825 ,(1975)
A Balsam, F Sexton, M Borges, S H Ingbar, Formation of diiodotyrosine from thyroxine. Ether-link cleavage, an alternate pathway of thyroxine metabolism. Journal of Clinical Investigation. ,vol. 72, pp. 1234- 1245 ,(1983) , 10.1172/JCI111079
Andrew Foldes, James L. Meek, Rat brain phenolsulfotransferase: partial purification and some properties. Biochimica et Biophysica Acta. ,vol. 327, pp. 365- 373 ,(1973) , 10.1016/0005-2744(73)90419-1
Ronald D. Sekura, William B. Jakoby, Aryl sulfotransferase IV from rat liver Archives of Biochemistry and Biophysics. ,vol. 211, pp. 352- 359 ,(1981) , 10.1016/0003-9861(81)90464-1
P. H. Yu, B. Rozdilsky, A. A. Boulton, Sulfate Conjugation of Monoamines in Human Brain: Purification and Some Properties of an Arylamine Sulfotransferase from Cerebral Cortex Journal of Neurochemistry. ,vol. 45, pp. 836- 843 ,(1985) , 10.1111/J.1471-4159.1985.TB04070.X
JAN A. MOL, THEO J. VISSER, Rapid and selective inner ring deiodination of thyroxine sulfate by rat liver deiodinase. Endocrinology. ,vol. 117, pp. 8- 12 ,(1985) , 10.1210/ENDO-117-1-8
Rajah S Sundaram, Jon A Van Loon, Richard Tucker, Richard M Weinshilboum, Sulfation pharmacogenetics: Correlation of human platelet and small intestinal phenol sulfotransferase Clinical Pharmacology & Therapeutics. ,vol. 46, pp. 501- 509 ,(1989) , 10.1038/CLPT.1989.178
Ronald T. Borchardt, Anna Baranczyk-Kuzma, Carol L. Pinnick, An Ecteola-cellulose chromatography assay for 3′-phosphoadenosine 5′-phosphosulfate: Phenol sulfotransferase Analytical Biochemistry. ,vol. 130, pp. 334- 338 ,(1983) , 10.1016/0003-2697(83)90596-1