Nitroprusside single-dose prevents the psychosis-like behavior induced by ketamine in rats for up to one week

摘要: Abstract Recently, we found a rapid and long-lasting improvement of symptoms in schizophrenic patients on antipsychotics after single four-hour infusion sodium nitroprusside (SNP), nitric oxide (NO) donor with short half-life. This persisted for up to 4 weeks. Because these remained SNP was finished, the question arises about whether this due itself. We have now investigated SNP, alone, can produce preventive antipsychotic effects rats treated ketamine (KET). 56 adult divided into 7 groups were infused 4 mg/kg, KET 25 mg/kg, or saline as follows: group1 — saline, group2 group3 KET, group4 12 h group5 1 day group6 2 days group7 1 week SNP. The animals filmed an open field arena 30 min videos later analyzed by ANY-Maze software measure activity stereotypy. significantly prevented emergence hyperactivity induced when it administered before stereotypies KET. These findings rats, which even faster metabolic rate than humans, suggest that observed our clinical trial humans could been itself, indicate first time may present effects.