Genetic variation in DTNBP1 influences general cognitive ability
作者： Katherine E. Burdick , Todd Lencz , Birgit Funke , Christine T. Finn , Philip R. Szeszko
DOI: 10.1093/HMG/DDI481
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摘要: Human intelligence is a trait that known to be significantly influenced by genetic factors, and recent linkage data provide positional evidence suggest region on chromosome 6p, previously associated with schizophrenia, may linked variation in intelligence. The gene for dysbindin-1 (DTNBP1) located at 6p has also been implicated neuropsychiatric disorder characterized cognitive dysfunction. We report an association between DTNBP1 genotype general ability (g) two independent cohorts, including 213 patients schizophrenia or schizo-affective 126 healthy volunteers. These influences human
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