An Increase in Herpes Simplex Virus Type 1 in the Anterior Segment of the Eye is Linked to a Deficiency in NK Cell Infiltration in Mice Deficient in CXCR3
作者： Daniel J.J. Carr , Todd Wuest , John Ash
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摘要: ABSTRACT In response to ocular herpes simplex virus type 1 (HSV-1) infection in mice, a rapid induction or increase the local expression of chemokines, including CXCL10, is found. The present study investigated role receptor for CXCR3, host corneal HSV-1 infection. Mice deficient CXCR3 (CXCR3−/−) were found have an infectious anterior segment eye by day 7 postinfection. Coinciding with increase, selective CCL2, CCL3, CCL5, CXCL9, and elevated HSV-1-infected CXCR3−/− mice. contrast, there was time-dependent reduction recruitment natural killer (NK) cells (NK1.1+CD3−) into A NK residing mice following antiasialoGM1 antibody treatment resulted virus. No other leukocyte populations infiltrating tissue modified absence of...
liebertonline.com参考文章(35)
Linda N. Stiles, Jenny L. Hardison, Chris S. Schaumburg, Lucia M. Whitman, Thomas E. Lane, T cell antiviral effector function is not dependent on CXCL10 following murine coronavirus infection. Journal of Immunology. ,vol. 177, pp. 8372- 8380 ,(2006) , 10.4049/JIMMUNOL.177.12.8372
Hiroaki Hemmi, Osamu Takeuchi, Taro Kawai, Tsuneyasu Kaisho, Shintaro Sato, Hideki Sanjo, Makoto Matsumoto, Katsuaki Hoshino, Hermann Wagner, Kiyoshi Takeda, Shizuo Akira, A Toll-like receptor recognizes bacterial DNA. Nature. ,vol. 408, pp. 740- 745 ,(2000) , 10.1038/35047123
Ming-Fang Hsieh, Szu-Liang Lai, Jia-Perng Chen, Jui-Ming Sung, Yi-Ling Lin, Betty A. Wu-Hsieh, Craig Gerard, Andrew Luster, Fang Liao, Both CXCR3 and CXCL10/IFN-Inducible Protein 10 Are Required for Resistance to Primary Infection by Dengue Virus Journal of Immunology. ,vol. 177, pp. 1855- 1863 ,(2006) , 10.4049/JIMMUNOL.177.3.1855
S Kanangat, B T Rouse, J Thomas, S Gangappa, On the essential involvement of neutrophils in the immunopathologic disease: herpetic stromal keratitis. Journal of Immunology. ,vol. 158, pp. 1383- 1391 ,(1997)
Richard B. Pollard, Tetsuo Fukumoto, Mitsunori Morimatsu, Fujio Suzuki, Kaori Ikemoto, Kaori Ikemoto, Small amounts of exogenous IL-4 increase the severity of encephalitis induced in mice by the intranasal infection of herpes simplex virus type 1. Journal of Immunology. ,vol. 155, pp. 1326- 1333 ,(1995)
B. M. Gebhardt, W. P. Halford, D. J. J. Carr, Persistent cytokine expression in trigeminal ganglion latently infected with herpes simplex virus type 1. Journal of Immunology. ,vol. 157, pp. 3542- 3549 ,(1996)
Homayon Ghiasi, Steve Cai, Guey-Chuen Perng, Anthony B Nesburn, Steven L Wechsler, The role of natural killer cells in protection of mice against death and corneal scarring following ocular HSV-1 infection. Antiviral Research. ,vol. 45, pp. 33- 45 ,(2000) , 10.1016/S0166-3542(99)00075-3
Ian Clark-Lewis, Ivan Mattioli, Jiang-Hong Gong, Pius Loetscher, Structure-Function Relationship between the Human Chemokine Receptor CXCR3 and Its Ligands Journal of Biological Chemistry. ,vol. 278, pp. 289- 295 ,(2003) , 10.1074/JBC.M209470200
Norimitsu Kadowaki, Svetlana Antonenko, Johnson Yiu-Nam Lau, Yong-Jun Liu, Natural Interferon α/β–Producing Cells Link Innate and Adaptive Immunity Journal of Experimental Medicine. ,vol. 192, pp. 219- 226 ,(2000) , 10.1084/JEM.192.2.219
M. Zheng, D. M. Klinman, M. Gierynska, B. T. Rouse, DNA containing CpG motifs induces angiogenesis Proceedings of the National Academy of Sciences of the United States of America. ,vol. 99, pp. 8944- 8949 ,(2002) , 10.1073/PNAS.132605599