Dynamic change in natural killer cell type in the human ocular mucosa in situ as means of immune evasion by adenovirus infection
作者： N Yawata , K J Selva , Y-C Liu , K P Tan , A W L Lee
DOI: 10.1038/MI.2015.47
关键词: Conjunctiva 、 NK Cell Lectin-Like Receptor Subfamily C 、 Immune system 、 Biology 、 Cell type 、 Natural killer cell 、 Inflammation 、 Immunology 、 Chemokine 、 Adenovirus infection
摘要: The most severe form of virus-induced inflammation at the ocular surface is epidemic keratoconjunctivitis (EKC), often caused by group D human adenoviruses (HAdVs). We investigated dynamics and mechanisms changes in natural killer (NK) cell types mucosal situ over course infection. In acute phase infection, mature CD56(dim)NK cells that comprise a major subpopulation normal conjunctiva are replaced CD56(bright)NK recruited to chemokines produced infected epithelium, NKG2A-expressing CD56(dim) CD56(bright) NK become subpopulations inflammation. These attracted however incapable mounting strong antiviral response because upregulation inhibitory ligand leukocyte antigen-E (HLA-E) on epithelium. Furthermore, HAdVs downregulate ligands for activating receptors, thus rendering even NKG2A(-)NK unresponsive, an immune-escape mechanism distinct from other adenoviruses. Our findings imply EKC-causing utilize these multiple pathways inhibit responses initial stages
nature.com
elsevier.com
sci-hub.se 参考文章(50)
Steven E. Wilson, Rahul R. Mohan, Rajiv R. Mohan, Renato Ambrósio, JongWook Hong, JongSoo Lee, The corneal wound healing response: cytokine-mediated interaction of the epithelium, stroma, and inflammatory cells. Progress in Retinal and Eye Research. ,vol. 20, pp. 625- 637 ,(2001) , 10.1016/S1350-9462(01)00008-8
Kirk R. Wilhelmus, Gary N. Holland, Jay S. Pepose, Ocular Infection and Immunity ,(1996)
H Körner, H G Burgert, Down-regulation of HLA antigens by the adenovirus type 2 E3/19K protein in a T-lymphoma cell line. Journal of Virology. ,vol. 68, pp. 1442- 1448 ,(1994) , 10.1128/JVI.68.3.1442-1448.1994
Aniki Rothova, Jonas Kuiper, Anjo Riemens, Elena. I. Stoyanova, Cytokines in tear fluid of patients with ocular graft-versus-host disease after allogeneic stem cell transplantation Molecular Vision. ,vol. 18, pp. 797- 802 ,(2012)
Chiara Romagnani, Kerstin Juelke, Michela Falco, Barbara Morandi, Antonella D’Agostino, Roberta Costa, Giovanni Ratto, Giuseppe Forte, Paolo Carrega, Gabrielle Lui, Romana Conte, Till Strowig, Alessandro Moretta, Christian Münz, Andreas Thiel, Lorenzo Moretta, Guido Ferlazzo, CD56brightCD16− Killer Ig-Like Receptor− NK Cells Display Longer Telomeres and Acquire Features of CD56dim NK Cells upon Activation Journal of Immunology. ,vol. 178, pp. 4947- 4955 ,(2007) , 10.4049/JIMMUNOL.178.8.4947
Daniel J.J. Carr, Todd Wuest, John Ash, An Increase in Herpes Simplex Virus Type 1 in the Anterior Segment of the Eye is Linked to a Deficiency in NK Cell Infiltration in Mice Deficient in CXCR3 Journal of Interferon and Cytokine Research. ,vol. 28, pp. 245- 251 ,(2008) , 10.1089/JIR.2007.0110
Megan A Cooper, Todd A Fehniger, Michael A Caligiuri, The biology of human natural killer-cell subsets. Trends in Immunology. ,vol. 22, pp. 633- 640 ,(2001) , 10.1016/S1471-4906(01)02060-9
Makoto Yawata, Nobuyo Yawata, Monia Draghi, Fotini Partheniou, Ann-Margaret Little, Peter Parham, MHC class I–specific inhibitory receptors and their ligands structure diverse human NK-cell repertoires toward a balance of missing self-response Blood. ,vol. 112, pp. 2369- 2380 ,(2008) , 10.1182/BLOOD-2008-03-143727
Srihari Narayanan, Adrian Glasser, Ying-Sheng Hu, Alison M. McDermott, The effect of interleukin-1 on cytokine gene expression by human corneal epithelial cells. Experimental Eye Research. ,vol. 80, pp. 175- 183 ,(2005) , 10.1016/J.EXER.2004.08.027
Dorothy K. Sojka, Zhigang Tian, Wayne M. Yokoyama, Tissue-Resident Natural Killer Cells and Their Potential Diversity Seminars in Immunology. ,vol. 26, pp. 127- 131 ,(2014) , 10.1016/J.SMIM.2014.01.010