O6-methylgaunine-DNA methyltransferase activity in cerebral gliomas : a guidance for nitrosourea treatment ?
作者： Katsuyoshi Mineura , Ichiro Izumi , Naoyuki Kuwahara , Masayoshi Kowada
DOI: 10.3109/02841869409098371
关键词:
摘要: The activity of O6-methylgaunine-DNA methyltransferase (O6-MT), which removes O6-methyl residues from O6-methyIguanine-DNA leading to cell death, has been reported correlate with sensitivity nitrosoureas used for chemotherapy gliomas. We determined O6-MT in tumors and matched brain tissue patients Histological diagnoses were: six malignant astrocytomas, two glioblastomas, oligodendrogliomas, one ependymoma, medulloblastoma. In all cases but one, the ranged widely 39 258 fmol/mg protein extract. wide range tumor may indicate varying degree nitrosoureas. tissue, available peritumoral region five cases, varied between 38 415 fmol/mg. Four regions showed a higher value than respective tumor, lower value.
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