Genomic damage in patients with type-2 diabetes mellitus.

摘要: DNA damage seems to play a role in the pathogenesis of type-2 diabetes mellitus (DM2) and its complications. Several vitro assays have been used measure damage. In present study, we aimed investigate frequency sister chromatid exchange (SCE) micronuclei (MN) DM2 patients compared with healthy controls. SCE MN tests were carried out blood-cell cultures from 50 30 healthy, age- sex-matched control subjects. The mean age was 58.12 +/- 13.39 years, duration 5.40 4.32 years. level HbAlc 8.93 2.56. Patients showed higher controls (7.11 1.14 4.96 0.92, p < 0.001). Furthermore, positively correlated plasma HbA1c (p 0.05), but there no significant correlation between SCE. On other hand, our result increase (3.45 1.01 per 1000 cells) relative that group (1.79 0.67 0.001), diabetes, MN. conclusion, these results suggest is condition genomic instability characterized by an increased Hyperglycemia-induced oxidative stress may be underlying factor frequency.