Gene polymorphisms of angiotensin II type 1 receptor and angiotensin-converting enzyme in two ethnic groups living in Zhejiang Province, China.

摘要: Keywords: Angiotensin receptor, Angiotensin- converting enzyme, Gene polymorphism, Chinese population Abstract Polymorphisms of ACE insertion/deletion (I/D) and angiotensin II type 1 receptor (AT1R) 1166A-C have been associated with many diseases, distributions their genotypes vary in different races populations. The aim this study was to investigate angiotensin-converting enzyme (ACE) AT1R Han She populations ZheJiang province. We determined 189 163 individuals. DNA extracted from peripheral blood samples. Analyses were performed by polymerase chain reaction (PCR) restriction fragment length polymorphism (RFLP). frequencies alleles among the sample (41.3%II, 41.3%ID, 17.5%DD; 61.9%I allele, 38.1%D allele) similar those individuals (39.9%II, 39.3%ID, 20.9%DD; 59.5%I 40.5%D allele), p=0.660; p=0.421. However, significant differences between men women observed, p=0.042, p=0.014. genotype allele (88.4%AA, 11.1%AC, 0.5%CC) (93.9%A 6.1%C) respectively. In they (78.0%AA, 21.3%AC, 0.6%CC) (89.0%A 11.0%C allele). found p=0.031, p=0.018, within subgroups women, p=0.010, p=0.021. There no (p=0.476, p=0.261). or significantly samples