Análise exploratória aplicada no estudo de medicamentos contendo piroxicam

作者: Graciele Parisotto , Jorcem Simon de Souza , Marco Flôres Ferrão , João Carlos Furtado , Rolf Fredi Molz

DOI: 10.1590/S1516-93322005000400013

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摘要: The identification of different pharmaceutical formulations with piroxicam was studied, using spectra diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS), in association hierarchical cluster analysis (HCA) technique. samples the 5 compounding pharmacies, containing 10 or 20 mg and its respective inactive ingredients, had been collected Nicolet Magna 550 spectrophotometer. For multivariate analysis, spectral information processed software package Pirouette® 2.7 Infometrix. dendograms constructed autoscaled data, multiplicative scatter correction (MSC), three types linkage methods: single, flexible incremental. By applying formation two distinct groups: one active principles another group ingredients proved. These results demonstrate that DRIFTS associated chemometrics tools, constitute a quality control alternative drugs production processes.

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