PF00299804, an Irreversible Pan-ERBB Inhibitor, Is Effective in Lung Cancer Models with EGFR and ERBB2 Mutations that Are Resistant to Gefitinib

作者: J. A. Engelman , K. Zejnullahu , C.-M. Gale , E. Lifshits , A. J. Gonzales

DOI: 10.1158/0008-5472.CAN-07-1885

关键词:

摘要: … the insertion ERBB2 mutant, we expressed wild-type ERBB2 or the common ERBB2 mutant … Furthermore, PF00299804 effectively inhibits the growth of the ERBB2 mutant (Ins G776V,C…

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