Analyse rétrospective de 108 carcinomes canalaires in situ mammaires traités par association radiochirurgicale

摘要: PURPOSE: To evaluate survival and prognostic factors of 108 patients with clinically or mammographically detected ductal carcinoma in situ (DCIS), treated from 1980 to 1996 by complete local excision followed external irradiation. PATIENTS AND METHODS: The median age was 51 (range 37-80). All the underwent surgery consisting a wide resection mammary gland harbouring tumour. surgical specimens were sent pathologists get information on histology margin clearance; all slides reviewed one us assess tumoral diameter. External beam therapy delivered within 8 weeks after surgery. prescribed irradiation dose 50 Gy 25 fractions be given 5 weeks. duration follow-up 93 months 40-173). RESULTS: There nine recurrence (8.3%); three had DCIS six developed invasive breast cancer. treatment consisted mastectomy without axillary dissection (eight cases) quadrantectomy (one case). 5-year 10-year ipsilateral recurrence-free rate respectively 92 89%. cause specific 100%. In univariate analysis, size>or=10 mm, age<45 years old status significant P=0,02, P=0,03, P=0,005; multivariate analysis (P<0,02). CONCLUSION: These results are keeping those literature. They could improved mass screening campaign, which is going since January 1990 among women aged 50-74 years.