Antifungal efficacy of liquid poloxamer 407-based emulsions loaded with sertaconazole nitrate.
作者： Tobias Kracht , Christel C. Müller-Goymann
DOI: 10.1016/J.IJPHARM.2020.119400
关键词:
摘要: Abstract Drug delivery into the human nail plate for treatment of onychomycosis is difficult due to limited permeability plate. Semisolid poloxamer 407-based formulations have recently shown promising results drug and through In this study, liquid emulsions loaded with sertaconazole nitrate been developed permeation behavior was determined in vitro using modified Franz diffusion cells. The antifungal efficacy evaluated an infected model, where growth inhibition Trichophyton rubrum observed. Bovine hoof plates keratin films made from hair were used as models both cases, low viscosity high water content showed best despite a lower solubility nitrate, suggesting that composition vehicle plays major role membrane. addition, API close saturation had positive effect on permeation.
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