Oral morphine multiparticulate formulation
作者： Sean Cunningham , Paul Stark , Jagathesan Moodley
DOI:
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摘要: An oral morphine multiparticulate formulation for once-daily administration to a patient, comprising sustained release particles each having core containing water soluble and an osmotic agent, the being coated with rate-controlling polymer coat comprised of ammonio methacrylate copolymers in amount sufficient achieve therapeutically effective plasma levels over at least 24 hours patient.
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