Novel Self-assembled, Gel-core Hyaluosomes for Non-invasive Management of Osteoarthritis: In-vitro Optimization, Ex-vivo and In-vivo Permeation
作者： Wessam M. El-Refaie , Yosra S. R. Elnaggar , Magda A. El-Massik , Ossama Y. Abdallah
DOI: 10.1007/S11095-015-1672-8
关键词:
摘要: Purpose Hyaluronic acid (HA) is an imperative biomaterial with desirable rheological properties to alleviate symptoms of osteoarthritis. Nevertheless, scantly percutaeous permeation this macromolecule handicaps its effective use for orthopedics and triggers intra-articular injection as the only surrogate. This study presents novel self-assembeld HA-based gel core elastic nanovesicles, (hyaluosomes; GC-HS), non-invasive transdermal delivery HA.
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