A Controlled Clinical Trial Including Folinic Acid at Two Distinct Dose Levels in Combination with 5-Fluorouracil (5FU) for the Treatment of Advanced Colorectal Cancer: Experience of the Mayo Clinic and North Central Cancer Treatment Group

摘要: A prospectively randomized clinical trial was conducted to determine the therapeutic effect of five individual combination chemotherapy regimens compared single agent FUra for treatment advanced colorectal cancer. For purposes this symposium, detailed results therapy will be presented only PTS treated with alone or + LV* in a high dose (200 mg/m2) low (20 daily days. Two hundred twelve were one these three regimens, and 208 (98%) available analysis. Median time from randomization is 18 months anproximately 70% have died. Both are associated significantly improved survival (p ≤ 0.03). In addition, interval-to-tumor-progression, measurable tumor response rates, measures quality life (performance status, weight gain, symptomatic relief) also addition LV*. The most favorable regimen based on considerations both cost. national intergroup examine efficacy surgical adjuvant setting.