Emetic responses to T-2 toxin, HT-2 toxin and emetine correspond to plasma elevations of peptide YY3-36 and 5-hydroxytryptamine.

摘要: Trichothecene mycotoxins are a family of potent translational inhibitors that associated with foodborne outbreaks human and animal gastroenteritis in which vomiting is clinical hallmark. Deoxynivalenol (DON, vomitoxin) other Type B trichothecenes have been previously demonstrated to cause emesis the mink (Neovison vison), this response has directly linked secretion both satiety hormone peptide YY3–36 (PYY3–36) neurotransmitter 5-hydroxytryptamine (5-HT). Here, we characterized emetic responses T-2 toxin (T-2) HT-2 (HT-2), two highly toxic A contaminate cereals, further compared these effects those emetine, natural alkaloid used medicinally also well known block translation vomiting. Following intraperitoneal (IP) oral exposure, all three agents caused evident dose-dependent increases duration number events as decreases latency emesis. doses causing 50 % treated animals (ED50s) were 0.05 0.02 mg/kg BW following IP administration, respectively, whereas ED50s for emetine 2.0 1.0 respectively. Importantly, administration toxins elicited marked elevations plasma concentrations PYY3–36 5-HT corresponded Taken together, results suggest much more than induction by co-occurred circulating levels 5-HT.