Role for interferon regulatory factors in autoimmunity
作者： Christophe Richez , Thomas Barnetche , Corinne Miceli-Richard , Patrick Blanco , Jean-François Moreau
DOI: 10.1016/J.JBSPIN.2010.08.005
关键词:
摘要: Interferon regulatory factors (IRFs) were first identified during studies of type I interferons. Since then, many investigations have established that IRFs are involved in regulating the innate immune response, development various cell types, and carcinogenesis. Several genetic variants, most notably IRF5, associated with an increased risk autoimmune disease. The biological role for diseases has been evaluated not only vitro, but also vivo murine models. Here, we discuss IRFs, particularly toll-like receptor signaling pathways. We review evidence supporting a dysimmune diseases.
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elsevier.com参考文章(84)
Christine L. Shaklee, Jane Guo, Giorgio Senaldi, Tak W. Mak, Thomas Boone, Laura Martin, Thomas R. Ulich, Protection Against the Mortality Associated with Disease Models Mediated by TNF and IFN-γ in Mice Lacking IFN Regulatory Factor-1 Journal of Immunology. ,vol. 163, pp. 6820- 6826 ,(1999)
Bruce Beutler, Ernst Th. Rietschel, Innate immune sensing and its roots: the story of endotoxin Nature Reviews Immunology. ,vol. 3, pp. 169- 176 ,(2003) , 10.1038/NRI1004
Karen E. Pinder, Betsy J. Barnes, Merrill J. Kellum, Paula M. Pitha, J. Augusto Frisancho, Interferon Regulatory Factor 5, a Novel Mediator of Cell Cycle Arrest and Cell Death Cancer Research. ,vol. 63, pp. 6424- 6431 ,(2003)
Christophe Richez, Kei Yasuda, Amanda A. Watkins, Shizuo Akira, Robert Lafyatis, Jean M. van Seventer, Ian R. Rifkin, TLR4 ligands induce IFN-alpha production by mouse conventional dendritic cells and human monocytes after IFN-beta priming Journal of Immunology. ,vol. 182, pp. 820- 828 ,(2009) , 10.4049/JIMMUNOL.182.2.820
Christophe Richez, Kei Yasuda, Ramon G. Bonegio, Amanda A. Watkins, Tamar Aprahamian, Patricia Busto, Rocco J. Richards, Chih Long Liu, Regina Cheung, Paul J. Utz, Ann Marshak-Rothstein, Ian R. Rifkin, IFN Regulatory Factor 5 Is Required for Disease Development in the FcγRIIB−/−Yaa and FcγRIIB−/− Mouse Models of Systemic Lupus Erythematosus Journal of Immunology. ,vol. 184, pp. 796- 806 ,(2010) , 10.4049/JIMMUNOL.0901748
S. M. McWhirter, K. A. Fitzgerald, J. Rosains, D. C. Rowe, D. T. Golenbock, T. Maniatis, IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts Proceedings of the National Academy of Sciences of the United States of America. ,vol. 101, pp. 233- 238 ,(2004) , 10.1073/PNAS.2237236100
S. Garnier, P. Dieude, L. Michou, S. Barbet, A. Tan, S. Lasbleiz, T. Bardin, B. Prum, F. Cornelis, , IRF5 rs2004640-T allele, the new genetic factor for systemic lupus erythematosus, is not associated with rheumatoid arthritis Annals of the Rheumatic Diseases. ,vol. 66, pp. 828- 831 ,(2007) , 10.1136/ARD.2006.061390
R. P. Donn, J. H. Barrett, A. Farhan, A. Stopford, L. Pepper, E. Shelley, N. Davies, W. E. R. Ollier, W. Thomson, , Cytokine gene polymorphisms and susceptibility to juvenile idiopathic arthritis Arthritis & Rheumatism. ,vol. 44, pp. 802- 810 ,(2001) , 10.1002/1529-0131(200104)44:4<802::AID-ANR136>3.0.CO;2-G
Thomas Krausgruber, David Saliba, Grigory Ryzhakov, Alessandra Lanfrancotti, Katrina Blazek, Irina A. Udalova, IRF5 is required for late-phase TNF secretion by human dendritic cells Blood. ,vol. 115, pp. 4421- 4430 ,(2010) , 10.1182/BLOOD-2010-01-263020
S Giannouli, D Tzoanopoulos, K Ritis, G Kartalis, HM Moutsopoulos, M Voulgarelis, Autoimmune manifestations in human myelodysplasia: a positive correlation with interferon regulatory factor-1 (IRF-1) expression Annals of the Rheumatic Diseases. ,vol. 63, pp. 578- 582 ,(2004) , 10.1136/ARD.2003.012948