Iron acquisition by Haemophilus influenzae.

摘要: The mechanisms for acquisition of iron by Haemophilus influenzae and their role in pathogenesis are not known. Heme nonheme sources were evaluated effect on growth type b nontypable strains H. an iron-restricted, defined medium. All 13 acquired from heme, hemoglobin, hemoglobin-haptoglobin, heme-hemopexin. Among protein-bound iron, was enhanced partially saturated human transferrin but lactoferrin or ferritin. Purified ferrienterochelin ferridesferrioxamine failed to provide influenzae, the supernatants E1a grown iron-restricted medium enhance siderophore-dependent Escherichia coli, Salmonella typhimurium, Arthrobacter terregens. Marked alterations profile outer membrane proteins observed when level free varied between 1 microM mM. Catechols detected strain E1a; however, iron-related hydroxamate production two biochemical assays. We conclude that diverse. significance is yet clear. Images