Fetal RhD genotyping by maternal serum analysis: a two-year experience.
作者： Evelyne Gautier , Alexandra Benachi , Yves Giovangrandi , Pauline Ernault , Martine Olivi
DOI: 10.1016/J.AJOG.2004.10.632
关键词:
摘要: Objective The purpose of this study was to determine the accuracy none-invasive prenatal determination polymerase chain reaction (PCR)-based fetal RhD genotyping. Study design A prospective case series undertaken on all RhD-negative pregnant women presenting for genetic counseling in our diagnosis center from January 2001 until December 2002. Results were compared with serologic typing newborns. Among 285 who participated study, status could be determined 283 patients. In 2 cases, phenotype mother not result a complete RHD gene deletion, and therefore, fetus determined. Neither false-negative nor false-positive results observed. Conclusion present report demonstrates that reliable genotype can achieved 100% accuracy. It is therefore possible consider such an assay systematically proposed order more effectively utilize prophylaxis.
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