Involvement of spinal cord BDNF in the generation and maintenance of chronic neuropathic pain in rats.

摘要: Brain-derived neurotrophic factor (BDNF) is involved in neuronal survival and synaptic plasticity of the central peripheral nervous system. In chronic pain, plastic changes dorsal horn neurons contribute to a phenomenon hypersensitivity pain sensation that maintained over time, known as sensitization. This process accompanied by BDNF overexpression, but role generation maintenance hyperalgesic still unclear. The present study was aimed investigate if exogenous administered rat spinal cord, addition trigger participates sensitization (i.e., persistence) determine generated comparable observed neuropathic model. Results showed single intrathecal injection 0.003 ng able decrease nociceptive threshold (Randall-Selitto test) normal rats, for at least 42-day period. Furthermore, hyperalgesia rats with history mononeuropathy. Increasing dose or administering additional doses resulted neither effectiveness reducing nor prolongation effect, thus showing induced dose-independent, all-or-none process. It concluded alone sufficient generating long-lasting neural excitability change cord via tyrosine kinase B receptor signaling, similar models such neuropathy.