RESEARCH ARTICLE: An Orthotopic Skull Base Model of Malignant Meningioma
作者： Gilson S. Baia , Eduard B. Dinca , Tomoko Ozawa , Edna T. Kimura , Michael W. McDermott
DOI: 10.1111/J.1750-3639.2007.00109.X
关键词:
摘要: Meningioma tumor growth involves the subarachnoid space that contains cerebrospinal fluid. Modeling in this microenvironment has been associated with widespread leptomeningeal dissemination, which is uncharacteristic of human meningiomas. Consequently, survival times and properties are varied, limiting their utility testing experimental therapies. We report development characterization a reproducible orthotopic skull-base meningioma model athymic mice using IOMM-Lee cell line. Localized was obtained by optimal densities matrigel as implantation medium. Survival were within narrow range 17-21 days. The xenografts grew locally compressing surrounding brain tissue. These tumors had histopathologic characteristics anaplastic meningiomas including high cellularity, nuclear pleomorphism, cellular pattern loss, necrosis conspicuous mitosis. Similar to meningiomas, considerable invasion dura skull some adjacent along perivascular tracts observed. hypoxia also similar malignant use bioluminescent imaging non-invasively monitor determine benefit from temozolomide treatment. Thus, we describe system will be useful for investigating biology preclinical assessment therapeutic agents.
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