Effect of race and histology on patterns of failure in women with early stage endometrial cancer treated with high dose rate brachytherapy.

摘要: Abstract Background Clinical trials have helped refine management of early stage endometrial cancer (EC). For patients with intermediate risk features, adjuvant radiation is considered, primarily vaginal cuff brachytherapy. higher patients, there may be a role for chemotherapy and radiation. The purpose this study to examine patterns failure EC treated postoperative high dose rate Methods In single institution retrospective cohort study, 208 women who received definitive therapy between January 1, 2000 2013 were identified. Results Median follow-up was 46.4 (range, 6.2–137.3) months. Thirteen (6.3%) developed locoregional recurrent disease 15 (7.2%) distant metastasis. Freedom from recurrence at 5years 88.6% white 60.5% black (p=0.0093). Five year free survival (RFS) vs. 82.9% 48.9% (p=0.0007). overall (OS) 86.8% 59.5% (p=0.0023). Black unfavorable histology brachytherapy had 15% rate, more than double the local compared AA endometrioid any (6% rate). Conclusions experience increased rates worse patients. Patterns in group also indicate (type II).