Clinical significance of microsatellite instability in endometrial carcinoma.

摘要: BACKGROUND The purpose of this study was to compare the clinical characteristics endometrial carcinomas with and without microsatellite instability (MSI). METHODS The authors prospectively acquired DNA from patients at Washington University Medical Center. Tumors were assigned MSI (+) status when two or more five repeat markers revealed novel bands in tumor not present corresponding normal DNA. Clinical survival data abstracted patient charts. Statistical significance calculated chi-square test, assessed Kaplan–Meier methods. RESULTS The found 65 70 (93%) tumors be white race, whereas only 124 159 (78%) (−) (P = 0.012). Advanced disease (International Federation Gynecology Obstetrics Stage III–IV) observed 9 (13%) 44 (28%) 0.017). In addition, aggressive histologic subtypes less frequently (6/70 [8%]) than (30 [19%]) 0.034). Race stage shown by multivariate analysis different patients. Recurrence overall similar groups. CONCLUSIONS Patients likely race early disease. Further investigation is needed explain why have tumors, despite presenting earlier stages, being associated virulent subtypes. Cancer 2000;89:1758–64. © 2000 American Society.