Vitamin D, respiratory infections, and asthma

摘要: Over the past decade, interest has grown in role of vitamin D many nonskeletal medical conditions, including respiratory infection. Emerging evidence indicates that D-mediated innate immunity, particularly through enhanced expression human cathelicidin antimicrobial peptide (hCAP-18), is important host defenses against tract pathogens. Observational studies suggest deficiency increases risk infections. This increased may contribute to incident wheezing illness children and adults cause asthma exacerbations. Although unproven, specific infections susceptible hosts some cases asthma. Vitamin also modulates regulatory T-cell function interleukin-10 production, which increase therapeutic response glucocorticoids steroid-resistant Future laboratory, epidemiologic, randomized interventional are needed better understand D’s effects on infection