Circulating fibroblast activation protein activity and antigen levels correlate strongly when measured in liver disease and coronary heart disease
作者： David Bowen , Mark Gorrell , Fiona Keane , Bhavri Maneck , Geoffrey William McCaughan
DOI: 10.1371/JOURNAL.PONE.0178987
关键词:
摘要: Background and aim Circulating fibroblast activation protein (cFAP) is a constitutively active enzyme expressed by activated fibroblasts that has both dipeptidyl peptidase endopeptidase activities. We aimed to assess the correlation between cFAP activity antigen levels compare variations in levels. Methods In plasma of 465 control individuals, 368 patients with coronary heart disease (CHD) 102 hepatitis C virus (HCV) infected severe liver before after transplant, were measured newly developed assay. In same samples, using commercially available ELISA. Correlation analyses performed calculating Pearson’s coefficient (ρ). Additionally, normal ranges, determinants differences cohorts anticoagulants investigated. Results cFAP significantly correlated controls (ρ: 0.660, p<0.001) CHD 0.709, p<0.001). HCV cohort lower samples taken transplantation (p<0.001) normalized toward healthy individuals. Furthermore, higher men associated body mass index. Also, EDTA as compared citrated from individuals. Conclusions For analyzing levels, either or can be investigate However, it importance blood are collected anticoagulant.
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