Inhalation of tobramycin in patients with cystic fibrosis: comparison of two methods.

摘要: Inhalant tobramycin is established in the treatment of cystic fibrosis patients. Conventional nebulizers require a large amount expensive compound, because only small fraction deposited targeted lung region. In contrast, techniques based on controlled inhalation allow high and reproducible deposition drug specific regions. our study we compared efficiency two conventional 16 patients aged 13-39 years. Inhalations with doses 300 mg 150 were performed twice daily for three days. The was measured by determination its serum concentration 1 h after end inhalation. mean FEV1 value 61% predicted, range 36%-116%. There no differences concentrations among days both methods (controlled inhalation: 0.983 +/-0.381(+/-SD) mg/l, 1.119+/-0.448 1.194+/-0.568 mg/l; 1.075+/-0.798 1.294 0.839 mg/l 1.269+/-0.767 Day 1, 2, 3, respectively). Even though double technique, there significant difference overall from (conventional 1.210+/-0.783 1.092+/-0.461 mg/l). addition, coefficient variation required time shorter than (42% vs. 65% 7-8 min 20 min, Our data suggest that can significantly reduce therapy, deposition, variability pulmonary dosage. It seems probable improve antibiotic prevention infection.