Modulators of mitochondrial protein import

作者: Michael A. Teitell , Samuel A. Hasson , Carla M. Koehler , Deepa Dabir , Kiyoko Miyata

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摘要: The present invention provides compounds that modulate protein translocation in mitochondria, compositions thereof, and methods of identifying, making using these.

参考文章(89)
Danielle Leuenberger, Sean P. Curran, David Wong, Carla M. Koehler, The role of Tim9p in the assembly of the TIM22 import complexes. Traffic. ,vol. 4, pp. 144- 152 ,(2003) , 10.1034/J.1600-0854.2003.00095.X
Benjamin S. Glick, Liza A. Pon, Isolation of highly purified mitochondria from Saccharomyces cerevisiae. Methods in Enzymology. ,vol. 260, pp. 213- 223 ,(1995) , 10.1016/0076-6879(95)60139-2
Ulrich Güldener, Susanne Heck, Thomas Fiedler, Jens Beinhauer, Johannes H Hegemann, A New Efficient Gene Disruption Cassette for Repeated Use in Budding Yeast Nucleic Acids Research. ,vol. 24, pp. 2519- 2524 ,(1996) , 10.1093/NAR/24.13.2519
Alessio Di Fonzo, Dario Ronchi, Tiziana Lodi, Elisa Fassone, Marco Tigano, Costanza Lamperti, Stefania Corti, Andreina Bordoni, Francesco Fortunato, Monica Nizzardo, Laura Napoli, Chiara Donadoni, Sabrina Salani, Francesca Saladino, Maurizio Moggio, Nereo Bresolin, Iliana Ferrero, Giacomo P. Comi, The mitochondrial disulfide relay system protein GFER is mutated in autosomal-recessive myopathy with cataract and combined respiratory-chain deficiency. American Journal of Human Genetics. ,vol. 84, pp. 594- 604 ,(2009) , 10.1016/J.AJHG.2009.04.004
George C. Shaw, John J. Cope, Liangtao Li, Kenneth Corson, Candace Hersey, Gabriele E. Ackermann, Babette Gwynn, Amy J. Lambert, Rebecca A. Wingert, David Traver, Nikolaus S. Trede, Bruce A. Barut, Yi Zhou, Emmanuel Minet, Adriana Donovan, Alison Brownlie, Rena Balzan, Mitchell J. Weiss, Luanne L. Peters, Jerry Kaplan, Leonard I. Zon, Barry H. Paw, Mitoferrin is essential for erythroid iron assimilation Nature. ,vol. 440, pp. 96- 100 ,(2006) , 10.1038/NATURE04512
Bryce A. Mendelsohn, Chunyue Yin, Stephen L. Johnson, Thomas P. Wilm, Lilianna Solnica-Krezel, Jonathan D. Gitlin, Atp7a determines a hierarchy of copper metabolism essential for notochord development Cell Metabolism. ,vol. 4, pp. 155- 162 ,(2006) , 10.1016/J.CMET.2006.05.001
Nadia Terziyska, Barbara Grumbt, Christian Kozany, Kai Hell, Structural and functional roles of the conserved cysteine residues of the redox-regulated import receptor Mia40 in the intermembrane space of mitochondria. Journal of Biological Chemistry. ,vol. 284, pp. 1353- 1363 ,(2009) , 10.1074/JBC.M805035200
Gabriele Cavallaro, Genome-wide analysis of eukaryotic twin CX9C proteins Molecular BioSystems. ,vol. 6, pp. 2459- 2470 ,(2010) , 10.1039/C0MB00058B
Hong Jin, Melanie May, Lisbeth Tranebjærg, Elaine Kendall, Gumersindo Fontán, John Jackson, S.H. Subramony, Fernando Arena, Herbert Lubs, Stephanie Smith, Roger Stevenson, Charles Schwartz, David Vetrie, A novel X-linked gene, DDP, shows mutations in families with deafness (DFN-1), dystonia, mental deficiency and blindness Nature Genetics. ,vol. 14, pp. 177- 180 ,(1996) , 10.1038/NG1096-177
Nils Wiedemann, Kaye N. Truscott, Sylvia Pfannschmidt, Bernard Guiard, Chris Meisinger, Nikolaus Pfanner, Biogenesis of the Protein Import Channel Tom40 of the Mitochondrial Outer Membrane: INTERMEMBRANE SPACE COMPONENTS ARE INVOLVED IN AN EARLY STAGE OF THE ASSEMBLY PATHWAY Journal of Biological Chemistry. ,vol. 279, pp. 18188- 18194 ,(2004) , 10.1074/JBC.M400050200