Modeling the calcium and phosphate mineralization of American lobster cuticle1

摘要: Bottom-up modeling of American lobster (Homarus americanus) cuticle explains architecture and function ab initio, from first principles, starting with synthesis component polymers progressively building composite structure that should explain observed properties. A top-down perspective decomposes the at top level structural complexity aiming to descend finest detail. Both approaches aim ultimately model same structure. Current bottom-up models do not succeed in explaining key functional detail identified by approaches. Top-down structures associated functions are valuable as bases for potential vulnerabilities microbial attack. An immediate objective is inform approach components critical function. features include protein expression mineral heterogeneity their structures. ...