Vascular Pathology as a Potential Therapeutic Target in SCI

摘要: Acute traumatic spinal cord injury (SCI) is characterized by a progressive secondary degeneration which exacerbates the loss of penumbral tissue and neurological function. Here, we first provide an overview known pathophysiological mechanisms involving injured microvasculature molecular regulators that contribute to dysfunction existing new blood vessels. We also highlight differences between ischemic injuries may yield clues as more devastating nature injuries, possibly toxicity associated with hemorrhage. discuss species implications for choosing models, their relevance utility translate treatments towards clinic. Throughout this review, potential opportunities proof-of-concept experimental studies targeting therapies endothelial cell-specific responses. Lastly, comment on need vascular be included in drug development non-invasive diagnostics such serum cerebrospinal fluid biomarkers imaging pathology.