Relationship between thallium-201 uptake and tumour proliferative ability in thyroid nodules.
作者： Norihiko Kume , Kazuyoshi Suga , Kazuya Nishigauchi , Mitsutoshi Kawamura , Naofumi Matsunaga
DOI: 10.1007/BF01247364
关键词:
摘要: To evaluate whether thallium-201 scan can reflect tumour proliferative activity in thyroid nodules. We compared the degree of 201T1 uptake with ability as assessed immunohistochmically by labelling index proliferating cell nuclear antigen (PCNA) malignant and benign The case material comprised ten 31 surgically resected nodules from a total 41 patients.201TI was performed 5 min (early scan) 2 h (delayed after intravenous injection 74 MBq of201Tl. of201TI visually divided into three grades [from (-) to (++)], its normal adjacent tissue. Immunohistochemical staining PCNA using monoclonal antibody for PC 10 on paraffin-embedded specimens. On both early delayed scans, mean an intense201T1, i.e. (++), significantly higher than that lower or negative uptake. correlation (P=0.009) (P=0.019). Our results indicate that201TI may nodules, this is especially true regard scans.
springer.com
sci-hub.se 参考文章(18)
Tadahiro Shimizu, Nobuteru Usuda, Takeshi Yamanda, Akira Sugenoya, Futoshi Iida, Proliferative activity of human thyroid tumors evaluated by proliferating cell nuclear antigen/cyclin immunohistochemical studies. Cancer. ,vol. 71, pp. 2807- 2812 ,(1993) , 10.1002/1097-0142(19930501)71:9<2807::AID-CNCR2820710920>3.0.CO;2-5
Joanne D. Elligsen, J.E. Thompson, H.E. Frey, J. Kruuv, Correlation of (Na+K+)-ATPase activity with growth of normal and transformed cells Experimental Cell Research. ,vol. 87, pp. 233- 240 ,(1974) , 10.1016/0014-4827(74)90475-3
M D Coltrera, A M Gown, PCNA/Cyclin expression and BrdU uptake define different subpopulations in different cell lines Journal of Histochemistry and Cytochemistry. ,vol. 39, pp. 23- 30 ,(1991) , 10.1177/39.1.1670579
CUMALI AKTOLUN, HIKMET BAYHAN, METIN KIR, Clinical Experience with Tc-99m MIBI Imaging in Patients with Malignant Tumors Preliminary Results and Comparison with TI-201 Clinical Nuclear Medicine. ,vol. 17, pp. 171- 176 ,(1992) , 10.1097/00003072-199203000-00003
K. SUGA, K. NISHIGAUCHI, T. FUJITA, T. NAKANISHI, Experimental evaluation of the usefulness of 201Tl-chloride scintigraphy for monitoring radiotherapeutic effects. Nuclear Medicine Communications. ,vol. 15, pp. 128- 139 ,(1994) , 10.1097/00006231-199403000-00002
P. A. Hall, D. A. Levison, A. L. Woods, C. C.-W. Yu, D. B. Kellock, J. A. Watkins, D. M. Barnes, C. E. Gillett, R. Camplejohn, R. Dover, N. H. Waseem, D. P. Lane, Proliferating cell nuclear antigen (PCNA) immunolocalization in paraffin sections: An index of cell proliferation with evidence of deregulated expression in some, neoplasms The Journal of Pathology. ,vol. 162, pp. 285- 294 ,(1990) , 10.1002/PATH.1711620403
Heikki Joensuu, Aapo Ahonen, PekkaJ. Klemi, 18F-fluorodeoxyglucose imaging in preoperative diagnosis of thyroid malignancy European Journal of Nuclear Medicine and Molecular Imaging. ,vol. 13, pp. 502- 506 ,(1988) , 10.1007/BF00256624
Yasuhiko Ito, Akira Muranaka, Tanekazu Harada, Akihiko Matsudo, Tsuneo Yokobayashi, Hideaki Terashima, Experimental study on tumor affinity of 201Tl-chloride European Journal of Nuclear Medicine and Molecular Imaging. ,vol. 3, pp. 81- 86 ,(1978) , 10.1007/BF00251628
Hironobu Ochi, Hisashi Sawa, Teruo Fukuda, Yuichi Inoue, Hideyuki Nakajima, Yasutami Masuda, Terue Okamura, Yasuto Onoyama, Seiji Sugano, Hiyoshi Ohkita, Yosyaku Tei, Kenjin Kamino, Yasutsugu Kobayashi, Thallium-201-chloride thyroid scintigraphy to evaluate benign and/or malignant nodules usefulness of the delayed scan Cancer. ,vol. 50, pp. 236- 240 ,(1982) , 10.1002/1097-0142(19820715)50:2<236::AID-CNCR2820500213>3.0.CO;2-V
T. Tsuji, P. Shrestha, K. Yamada, H. Takagi, F. Shinozaki, K. Sasaki, K. Maeda, M. Mori, Proliferating cell nuclear antigen in malignant and pre-malignant lesions of epithelial origin in the oral cavity and the skin: an immunohistochemical study. Virchows Archiv. ,vol. 420, pp. 377- 383 ,(1992) , 10.1007/BF01600508