Nicotine-mediated cell proliferation and angiogenesis: new twists to an old story.

摘要: Tobacco smoking is one of the major etiologic factors associated with cancer. While there are many carcinogenic compounds present in tobacco smoke, its main addictive component, nicotine, not by itself. The properties nicotine achieved through nicotinic acetylcholine receptors (nAChRs) that widely distributed brain and neuromuscular junctions; at same time, they were found to be expressed a variety non-neuronal tissues body including those lung. Recent studies show these nAChRs can induce cell proliferation angiogenesis. Analysis molecular mechanisms underlying nicotine-mediated showed involvement Src kinase scaffolding protein β-arrestin-1. Further, activate basic components cycle machinery similar growth factor receptors. This involved increased binding Raf-1 Rb protein, activation cyclins D E as well ind...