Plasma and tissue levels of furosemide in dogs and monkeys following single and multiple oral doses.

摘要: 35S-Furosemide was administered to beagle dogs and rhesus monkeys as an oral solution on a single 20 repeated 5 mg/kg/day dosing regimen. In both species, furosemide is rapidly but incompletely absorbed with peak plasma levels being achieved within one hour after dosing. The level versus time profiles do not appear be significantly altered result of the repetitive regimen employed, although themselves are quite different for two species studied. Following doses, observed in approximately eight-fold higher than monkeys. dogs, administration results biexponential disposition curve while profile appears monoexponential. major phase has half-life or 30 minutes followed by slow elimination 7 hours. Only small percentage dose affected consequently accumulation once-daily slight. monkey studies, rapid had 11 On regimen, appeared accumulate slightly greater extnet dog showed lesser degree fluctuation interval. liver kidney radioactivity were detectable three days low and/or metabolites six following last multiple At dosage no unusual "typical" lesions associated found tissues examined histopathologically.