Comparative pharmacokinetics of frusemide in female rhesus monkeys, cynomolgus monkeys and baboons

摘要: Abstract 1. The pharmacokinetics of frusemide have been compared in 3 non-human primate species after a single intravenous dose mg/kg the drug. 2. Peak mean plasma concentrations were 31.6, 33.6, 43.6 μg/ml rhesus monkey, cynomolgus monkey and baboon respectively, declined with half-life about 20 min. 3. There no notable differences pharmacokinetic parameters estimated from either one-compartment or two-compartment open model. 4. statistically significant species-related clearance, half-lives volumes distribution adjusted for bodyweight. 5. are closer to those man than other commonly used laboratory animal species.