Curcumin/Liposome Nanotechnology as Delivery Platform for Anti-inflammatory Activities via NFkB/ERK/pERK Pathway in Human Dental Pulp Treated With 2-HydroxyEthyl MethAcrylate (HEMA).
作者： Bruna Sinjari , Jacopo Pizzicannella , Marco D’Aurora , Romina Zappacosta , Valentina Gatta
关键词:
摘要: Curcumin, primary component of the spice turmeric extracted from rhizomes Curcuma longa, represents major anti-oxidant and anti-inflammatory substance found in turmeric, acting thought various mechanisms not completely understood. Curcumin modulates cytokines, growth factors, transcription inflammatory molecules cell signaling pathways. During restorative dentistry practice, free resin monomers 2-hydroxyethyl methacrylate (HEMA) propagate through dentin micro-channel pulp into bloodstream affecting cellular integrity. The study highlights significance application curcumin bioactive liposomal formulations (CurLIP) to restore homeostasis dental stem cells (hDPSCs) response 3 5 mmol L-1 HEMA treatment. Cell proliferation combination with changes morphological features, proinflammatory cytokines secretion as Interleukin (IL) 6, IL8, Monocyte Chemoattractant Protein-1 (MCP1) Interferon-gamma (IFNγ) were assayed along nuclear factor (NF)-kB, an inducible involved activation several processes associated extracellular signal-regulated kinases (ERK) posphorylated (p-) ERK pathway. Our results showed a decreased proliferation, upregulation IL6, MCP1 IFNγ presence CurLIP therapy hDPSCs provokes increase block inhibitory regulation NFkB/ERK pERK cascade. natural nanocarrier influences numerous biochemical molecular cascades causing properties treatment human cells, representing innovative endodontic formulation able improve quality care community impact.
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sci-hub.se 参考文章(64)
Shatadal Ghosh, Sharmistha Banerjee, Parames C. Sil, The beneficial role of curcumin on inflammation, diabetes and neurodegenerative disease: A recent update. Food and Chemical Toxicology. ,vol. 83, pp. 111- 124 ,(2015) , 10.1016/J.FCT.2015.05.022
Sebastiano Gangemi, Paola L. Minciullo, Marco Miroddi, Ioanna Chinou, Gioacchino Calapai, Richard J. Schmidt, Contact dermatitis as an adverse reaction to some topically used European herbal medicinal products - part 2: Echinacea purpurea-Lavandula angustifolia. Contact Dermatitis. ,vol. 72, pp. 193- 205 ,(2015) , 10.1111/COD.12328
O. Trubiani, S. Caputi, D. Di Iorio, M. D’Amario, M. Paludi, R. Giancola, F. Di Nardo Di Maio, F. De Angelis, C. D’Arcangelo, The cytotoxic effects of resin-based sealers on dental pulp stem cells International Endodontic Journal. ,vol. 43, pp. 646- 653 ,(2010) , 10.1111/J.1365-2591.2010.01720.X
O. Trubiani, A. Cataldi, F. De Angelis, C. D’Arcangelo, S. Caputi, Overexpression of interleukin-6 and -8, cell growth inhibition and morphological changes in 2-hydroxyethyl methacrylate-treated human dental pulp mesenchymal stem cells. International Endodontic Journal. ,vol. 45, pp. 19- 25 ,(2012) , 10.1111/J.1365-2591.2011.01942.X
P C Heinrich, J V Castell, T Andus, Interleukin-6 and the acute phase response Biochemical Journal. ,vol. 265, pp. 621- 636 ,(1990) , 10.1042/BJ2650621
A. Manescu, A. Giuliani, S. Mohammadi, G. Tromba, S. Mazzoni, F. Diomede, N. Zini, A. Piattelli, O. Trubiani, Osteogenic potential of dualblocks cultured with human periodontal ligament stem cells: in vitro and synchrotron microtomography study. Journal of Periodontal Research. ,vol. 51, pp. 112- 124 ,(2016) , 10.1111/JRE.12289
Tsukasa Suzuki, Swadesh K. Das, Hirohumi Inoue, Machiko Kazami, Okio Hino, Toshiyuki Kobayashi, Raymond S. Yeung, Ken-Ichi Kobayashi, Tadahiro Tadokoro, Yuji Yamamoto, Tuberous sclerosis complex 2 loss-of-function mutation regulates reactive oxygen species production through Rac1 activation. Biochemical and Biophysical Research Communications. ,vol. 368, pp. 132- 137 ,(2008) , 10.1016/J.BBRC.2008.01.077
Jean-Marc Zingg, Syeda T. Hasan, Mohsen Meydani, Molecular mechanisms of hypolipidemic effects of curcumin Biofactors. ,vol. 39, pp. 101- 121 ,(2013) , 10.1002/BIOF.1072
F. Fioretti, C. Mendoza-Palomares, M. C. Avoaka-Boni, J. Ramaroson, S. Bahi, L. Richert, F. Granier, N. Benkirane-Jessel, Y. Haikel, Nano-odontology: nanostructured assemblies for endodontic regeneration. Journal of Biomedical Nanotechnology. ,vol. 7, pp. 471- 475 ,(2011) , 10.1166/JBN.2011.1312
Min Young Um, Kwang Hyun Hwang, Jiyun Ahn, Tae Youl Ha, Curcumin attenuates diet-induced hepatic steatosis by activating AMP-activated protein kinase. Basic & Clinical Pharmacology & Toxicology. ,vol. 113, pp. 152- 157 ,(2013) , 10.1111/BCPT.12076