Circulating amino acids are associated with bone mineral density decline and ten-year major osteoporotic fracture risk in older community-dwelling adults.

摘要: With aging, poor bone mineral density (BMD) and accelerated decrease in BMD are strong risk factors for fracture. Reports of the associations dietary protein intake with strength inconsistent, possibly owing to differences sources amino acid (AA) composition. We examined serum AA 4-year hip loss subsequent fracture within 10 years older community-dwelling adults, further addressed whether lifestyle, its source, body composition would affect associations. In 1424 men 1573 women (mean age 72 years), using binary logistic regression, higher valine, leucine, isoleucine tryptophan concentrations were associated (or approaching a borderline significance case last three ones) less decline (defined as ≥ 2.8 times precision error measurement at femoral neck) 4 later, OR (95%CI) /SD increase, ranging from 0.83 (0.75, 0.91) 0.92 (0.87, 0.98) after multiple adjustments baseline age, gender, BMI, BMD, estimated glomerular filtration rate (eGFR), (animal- plant-derived intakes), calcium intake, established lifestyles (physical activity level, smoking alcohol drinking status), osteoporosis medications, changes fat lean muscle mass. Higher total homocysteine (tHcy) concentration was independently later (OR 1.16 (1.05, 1.27)). Using multivariate Cox potentially predicted low incident major osteoporotic fractures (MOFs) (HR/SD (95%CI)=0.86 0.98)) adjustments. tHcy MOFs (95%CI)=1.29 (1.12, 1.50)) men. These findings suggest that specific profile correlates greater lower risk, independent diet lifestyle factors.