SC1/hevin identifies early white matter injury after ischemia and intracerebral hemorrhage in young and aged rats.

摘要: The progression of white matter damage after ischemic and hemorrhagic strokes can exacerbate the initial injury, but little is known about processes involved. We show that antiadhesive matricellular glycoprotein SC1 a novel early marker in 3 models acute injury rat striatum: transient focal ischemia, intracerebral hemorrhage, needle penetration wound. was restricted to damaged portions axon bundles bordered stroke lesions young-adult aged rats. peaked at 1 days hemorrhage 7 ischemia. SC1-positive usually expressed degraded myelin basic protein amyloid precursor protein, axonal injury. At hematoma edge, seen few retained staining. In these bundles, punctate staining filled individual axons, extended beyond core pan-axonal neurofilament NF200 inside or overlapped with when it present. Aged rats had less (and protein) both types stroke, suggesting reduced response. also labeled protein-positive along tract saline-injected rats; thus, appears characterize striatal multiple