Influence of cortico-striatal afferents on striatal kainic acid neurotoxicity
作者： Kathleen Biziere , Joseph T. Coyle
DOI: 10.1016/0304-3940(78)90140-4
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摘要: Abstract Decortication, which causes degeneration of the cortico-striatal glutamateric afferents, markedly attentuates neurotoxic action kainic acid in striatum. Injection 1 μmol L-glutamate alone decorticate striatum does not cause neuronal whereas injection 10 nmol kainate with partially restores kainate's neurotoxicity. The results suggest that neurotoxicity is affected by synaptic input to vulnerable neurons and may involve a cooperative interaction synaptically released L-glutamate.
sci-hub.se 参考文章(20)
L.T. Graham, M.H. Aprison, Fluorometric determination of aspartate, glutamate, and γ-aminobutyrate in nerve tissue using enzymic method Analytical Biochemistry. ,vol. 15, pp. 487- 497 ,(1966) , 10.1016/0003-2697(66)90110-2
John C. Hedreen, Corticostriatal cells identified by the peroxidase method. Neuroscience Letters. ,vol. 4, pp. 1- 7 ,(1977) , 10.1016/0304-3940(77)90115-X
JOSEPH T. COYLE, ROBERT SCHWARCZ, Lesion of striatal neurons with kainic acid provides a model for Huntington's chorea Nature. ,vol. 263, pp. 244- 246 ,(1976) , 10.1038/263244A0
J. P. Bennett, W. J. Logan, S. H. Snyder, AMINO ACIDS AS CENTRAL NERVOUS TRANSMITTERS: THE INFLUENCE OF IONS, AMINO ACID ANALOGUES, AND ONTOGENY ON TRANSPORT SYSTEMS for l‐GLUTAMIC AND l‐ASPARTIC ACIDS AND GLYCINE INTO CENTRAL NERVOUS SYNAPTOSOMES OF THE RAT Journal of Neurochemistry. ,vol. 21, pp. 1533- 1550 ,(1973) , 10.1111/J.1471-4159.1973.TB06037.X
E. G. MCGEER, P. L. MCGEER, Duplication of biochemical changes of Huntington's chorea by intrastriatal injections of glutamic and kainic acids Nature. ,vol. 263, pp. 517- 519 ,(1976) , 10.1038/263517A0
E.G. McGeer, P.L. McGeer, K. Singh, Kainate-induced degeneration of neostriatal neurons: dependency upon corticostriatal tract. Brain Research. ,vol. 139, pp. 381- 383 ,(1978) , 10.1016/0006-8993(78)90941-1
R. Herndon, J. Coyle, Selective destruction of neurons by a transmitter agonist Science. ,vol. 198, pp. 71- 72 ,(1977) , 10.1126/SCIENCE.197604
ROBERT SCHWARCZ, IAN CREESE, JOSEPH T. COYLE, SOLOMON H. SNYDER, Dopamine receptors localised on cerebral cortical afferents to rat corpus striatum Nature. ,vol. 271, pp. 766- 768 ,(1978) , 10.1038/271766A0
Jin-soo Kim, Rolf Hassler, Pat Haug, Kwang-Se Paik, Effect of frontal cortex ablation on striatal glutamic acid level in rat. Brain Research. ,vol. 132, pp. 370- 374 ,(1977) , 10.1016/0006-8993(77)90430-9
Robert Schwarcz, Joseph T. Coyle, Striatal lesions with kainic acid: neurochemical characteristics. Brain Research. ,vol. 127, pp. 235- 249 ,(1977) , 10.1016/0006-8993(77)90538-8