Methods and compositions for combating HIV infection
作者： Peter Jonathan Gasking Butler , Jonathan Karn , Rodney Warren Zemmel , Alistair Simpson Irvine , Roger K. Craig
DOI:
关键词:
摘要: The invention relates to an isolated nucleic acid comprising two operatively linked binding sites for HIV Rev protein, the a nucleation motif and oligomerization motif, wherein binds protein monomers with higher degree of cooperativity than wild-type RRE.
google.nl 参考文章(40)
U. Fischer, S. Meyer, M. Teufel, C. Heckel, R. Lührmann, G. Rautmann, Evidence that HIV-1 Rev directly promotes the nuclear export of unspliced RNA The EMBO Journal. ,vol. 13, pp. 4105- 4112 ,(1994) , 10.1002/J.1460-2075.1994.TB06728.X
J. Kjems, B.J. Calnan, A.D. Frankel, P.A. Sharp, Specific binding of a basic peptide from HIV-1 Rev. The EMBO Journal. ,vol. 11, pp. 1119- 1129 ,(1992) , 10.1002/J.1460-2075.1992.TB05152.X
Tominori Kimura, Akio Ohyama, Interaction with the Rev Response Element along an Extended Stem I Duplex Structure Is Required to Complete Human Immunodeficiency Virus Type 1 rev-Mediated trans-Activation In Vivo The Journal of Biochemistry. ,vol. 115, pp. 945- 952 ,(1994) , 10.1093/OXFORDJOURNALS.JBCHEM.A124443
S M Holland, M Chavez, S Gerstberger, S Venkatesan, A specific sequence with a bulged guanosine residue(s) in a stem-bulge-stem structure of Rev-responsive element RNA is required for trans activation by human immunodeficiency virus type 1 Rev. Journal of Virology. ,vol. 66, pp. 3699- 3706 ,(1992) , 10.1128/JVI.66.6.3699-3706.1992
E T Dayton, D A Konings, D M Powell, B A Shapiro, L Butini, J V Maizel, A I Dayton, Extensive sequence-specific information throughout the CAR/RRE, the target sequence of the human immunodeficiency virus type 1 Rev protein. Journal of Virology. ,vol. 66, pp. 1139- 1151 ,(1992) , 10.1128/JVI.66.2.1139-1151.1992
Michael John Gait, Colin Dingwall, Jonathan Karn, Shaun Heaphy, Viral growth inhibition ,(1991)
X J Huang, T J Hope, B L Bond, D McDonald, K Grahl, T G Parslow, Minimal Rev-response element for type 1 human immunodeficiency virus. Journal of Virology. ,vol. 65, pp. 2131- 2134 ,(1991) , 10.1128/JVI.65.4.2131-2134.1991
M H Malim, B R Cullen, Rev and the fate of pre-mRNA in the nucleus: implications for the regulation of RNA processing in eukaryotes. Molecular and Cellular Biology. ,vol. 13, pp. 6180- 6189 ,(1993) , 10.1128/MCB.13.10.6180
Wei Wen, Judy L Meinkotht, Roger Y Tsien, Susan S Taylor, Identification of a signal for rapid export of proteins from the nucleus Cell. ,vol. 82, pp. 463- 473 ,(1995) , 10.1016/0092-8674(95)90435-2
Michael H. Malim, Joachim Hauber, Shu-Yun Le, Jacob V. Maizel, Bryan R. Cullen, The HIV-1 rev trans-activator acts through a structured target sequence to activate nuclear export of unspliced viral mRNA. Nature. ,vol. 338, pp. 254- 257 ,(1989) , 10.1038/338254A0