Viral growth inhibition
作者： Michael John Gait , Colin Dingwall , Jonathan Karn , Shaun Heaphy
DOI:
关键词:
摘要: A synthetic molecule comprises at least one oligonucleotide comprising an RNA binding sequence or sequences corresponding to the site bound by HIV protein rev and capable of within cells. The sequences, cells, can act cause inhibition growth any present in so has potential therapeutic use treatment patients infected with HIV. invention also provides assay for identifying compounds that inhibit binding.
lens.org 参考文章(12)
Timothy A. Vickers, Thomas W. Bruice, David J. Ecker, Reagents and methods for modulating gene expression through rna mimicry ,(1991)
David J. Ecker, Antisense inhibitors of the human immunodeficiency virus phosphorothioate oligonucleotides ,(1990)
M J Selby, E S Bain, P A Luciw, B M Peterlin, Structure, sequence, and position of the stem-loop in tar determine transcriptional elongation by tat through the HIV-1 long terminal repeat. Genes & Development. ,vol. 3, pp. 547- 558 ,(1989) , 10.1101/GAD.3.4.547
Sandy Feng, Eric C. Holland, HIV-1 tat trans-activation requires the loop sequence within tar Nature. ,vol. 334, pp. 165- 167 ,(1988) , 10.1038/334165A0
Robert A. Marciniak, Barbara J. Calnan, Alan D. Frankel, Phillip A. Sharp, HIV-1 Tat protein trans-activates transcription in vitro Cell. ,vol. 63, pp. 791- 802 ,(1990) , 10.1016/0092-8674(90)90145-5
G. J. Graham, J. J. Maio, RNA transcripts of the human immunodeficiency virus transactivation response element can inhibit action of the viral transactivator. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 87, pp. 5817- 5821 ,(1990) , 10.1073/PNAS.87.15.5817
A. W. Cochrane, C. H. Chen, C. A. Rosen, Specific interaction of the human immunodeficiency virus Rev protein with a structured region in the env mRNA Proceedings of the National Academy of Sciences of the United States of America. ,vol. 87, pp. 1198- 1202 ,(1990) , 10.1073/PNAS.87.3.1198
H Mitsuya, R Yarchoan, S Broder, Molecular targets for AIDS therapy Science. ,vol. 249, pp. 1533- 1544 ,(1990) , 10.1126/SCIENCE.1699273
Bruce A. Sullenger, Humilidad F. Gallardo, Grace E. Ungers, Eli Gilboa, Overexpression of TAR sequences renders cells resistant to human immunodeficiency virus replication Cell. ,vol. 63, pp. 601- 608 ,(1990) , 10.1016/0092-8674(90)90455-N
C. Dingwall, I. Ernberg, M. J. Gait, S. M. Green, S. Heaphy, J. Karn, A. D. Lowe, M. Singh, M. A. Skinner, R. Valerio, Human immunodeficiency virus 1 tat protein binds trans-activation-responsive region (TAR) RNA in vitro Proceedings of the National Academy of Sciences of the United States of America. ,vol. 86, pp. 6925- 6929 ,(1989) , 10.1073/PNAS.86.18.6925