Targeting telomerase-expressing cancer cells
作者： Michel M. Ouellette , Woodring E. Wright , Jerry W. Shay
DOI: 10.1111/J.1582-4934.2011.01279.X
关键词:
摘要: The role of telomeres and telomerase as a target for cancer therapeutics is an area continuing interest. This review intended to provide update on the field, pointing areas in which our knowledge remains deficient exploring details most promising being advanced into clinical trials. Topics that will be covered include dysfunctional cellular aging how replicative senescence provides initial barrier emergence immortalized cells, hallmark cancer. As important translational theme, this consider possibilities selectively targeting enhance therapy. immunotherapy, gene therapy approach using promoter driven oncolytic viruses small oligonucleotide targeted (Imetelstat) discussed.
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