Liberalization of donor criteria may expand the donor pool without adverse consequence in lung transplantation

摘要: Abstract Background: Currently the most important limitation in lung transplantation is donor availability. Although liberalization of criteria may aid expanding pool, long-term effects use “marginal” or “extended” donors remains unexplored. Methods: In this study, we included all patients who underwent from January 1996 to December 1999 at Loyola University Medical Center. We categorized as either receiving lungs an “ideal” donor. Extended were defined having any 1 following criteria: age > 55 years, tobacco history 20 pack presence infiltrate on chest x-ray, ventilator time 5 days, inhaled drugs (cocaine marijuana). then compared 2 groups with regard short-term (operating room [OR] complications, intensive care unit [ICU] complications) and outcomes (1-year pulmonary function survival). Results: Sixty-one (54%) received ideal 52 (46%) extended above. observed no significant differences between OR complications (cardiopulmonary bypass, bleeding life-threatening arrhythmias) ICU (pneumonia, airway dehiscence, reoperation within 30 days related transplantation). addition, had similar median intubation times (21 hours group group; p = n.s.), hospital length stay (14 ± 12 8 survival (80% 88% groups, respectively). One-year follow-up revealed (forced expiratory volume sec [FEV ] 2.4 liters recipients bilateral donors, respectively, FEV 1.9 1.5 single donors) (72% 79% respectively; n.s.) groups. Conclusions: Liberalization does not affect outcome first year after transplantation. By liberalizing criteria, can expand pool while assessing other possible mechanisms increase