ADAM9 Expression Is Associate with Glioma Tumor Grade and Histological Type, and Acts as a Prognostic Factor in Lower-Grade Gliomas.

摘要: The A disintegrin and metalloproteinase 9 (ADAM9) protein has been suggested to promote carcinoma invasion appears be overexpressed in various human cancers. However, its role rarely investigated gliomas and, thus, the current study we have evaluated ADAM9 expression examined relevance of prognosis glioma patients. Clinical characteristics, RNA sequence data, case follow-ups were reviewed for 303 patients who had histological, confirmed gliomas. between lower-grade (LGG) glioblastoma (GBM) was compared association with progression-free survival (PFS) overall (OS) assessed evaluate prognostic value. Our data that GBM significantly higher comparison LGG (p < 0.001, t-test). In addition, among patients, aggressive astrocytic tumors displayed than oligodendroglial Moreover, high also correlated poor clinical outcome 0.001 p log-rank test, PFS OS, respectively) Further, multivariate analysis an independent marker = 0.002 0.003, respectively). These results suggest mRNA is associated tumor grade histological type can serve as factor, specifically