Visceral leishmaniasis resembling systemic lupus erythematosus

摘要: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease of unknown aetiology. B cell hyperactivity with production multiple autoantibodies the hallmark disease.1 On other hand, such polyclonal activation may occur in infectious diseases. In this report we present patient visceral leishmaniasis who was diagnosed as having SLE and discuss clinical laboratory findings which discriminate between these two entities. A 50 year old man presented October 2001 arthralgias, fatigue, weight loss, low grade fever. Laboratory evaluation revealed haemoglobin 110 g/l, white blood cells 3.9×109/l normal differential count, platelets 90×109/l, erythrocyte sedimentation rate (ESR) mm/1st h. He admitted to hospital where physical examination disclosed mild splenomegaly. A investigation confirmed anaemia, leucopenia, thrombocytopenia, increased ESR C reactive protein (CRP) (table 1). Renal, liver thyroid …