Major carcinogenic pathways identified by gene expression analysis of peritoneal mesotheliomas following chemical treatment in F344 rats.
作者： Yongbaek Kim , Thai-Vu Ton , Anthony B. DeAngelo , Kevin Morgan , Theodora R. Devereux
DOI: 10.1016/J.TAAP.2005.12.009
关键词:
摘要: Abstract This study was performed to characterize the gene expression profile and identify major carcinogenic pathways involved in rat peritoneal mesothelioma (RPM) formation following treatment of Fischer 344 rats with o-nitrotoluene (o-NT) or bromochloracetic acid (BCA). Oligo arrays, over 20,000 target genes, were used evaluate o-NT- BCA-induced RPMs, when compared a non-transformed mesothelial cell line (Fred-PE). Analysis using Ingenuity Pathway software revealed 169 cancer-related genes that categorized into binding activity, growth proliferation, cycle progression, apoptosis, invasion metastasis. The microarray data validated by positive correlation quantitative real-time RT-PCR on 16 selected including igf1, tgfb3 nov. Important RPM included insulin-like factor 1 (IGF-1), p38 MAPkinase, Wnt/β-catenin integrin signaling pathways. demonstrated mesotheliomas exposed BCA similar humans, at least cellular molecular level.
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